Tried deleting my entire appdata/natural selection 2 folder and no dice. At this point I'm thinking it's something gone batty with my windows install. Tried updating video drivers as well, didn't solve anything.
I've attempted to replace the LUA twice, as well as the cache. Still no luck, so if the devs want a broken copy I can hook them up. I'm at a loss at this point, guess I'll send them an email.