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Pokemon X and Y come to mind. If you saved in a certain spot, you would become unable to load your save. It has since been patched, but that was a AAA fully released game, not an Early Access/Game Preview.
I can't figure out screenshots, but I can type up the error I got:
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Before my most recent play session, I had already explored both islands, and watched the Sunbeam explode (RIP). I built a base in the Safe Shallows near my life…