Hiv Defeated?

OmegamanOmegaman Join Date: 2004-01-11 Member: 25239Members
<div class="IPBDescription">New drug with almost no side effects...</div> <a href='http://www.asahi.com/english/Herald-asahi/TKY200507070204.html' target='_blank'>http://www.asahi.com/english/Herald-asahi/...0507070204.html</a>

<!--QuoteBegin--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> </td></tr><tr><td id='QUOTE'><!--QuoteEBegin-->A durable new drug that prevents HIV from entering human cells and causes almost no side effects has been developed by a team of researchers at Kumamoto University.

The new drug, code named AK602, was reported by the research team's leader, Hiroaki Mitsuya, at the International Congress on AIDS in Asia and the Pacific in Kobe on Tuesday.

The drug's main feature is that it shuts out the AIDS virus at the point when it tries to intrude into a human cell.

Current AIDS medicines can lose their effectiveness in a few days when the virus changes and develops a resistance to those drugs. But AK602 is different because it reacts to human cells instead of attacking the virus, Mitsuya said.

He said the drug sticks to a protein called CCR5 that acts as an entrance into human cells for the AIDS virus. When the new drug becomes attached to the protein, it can prevent HIV from entering, and thus stop the virus from spreading.

The researchers conducted clinical tests on 40 AIDS patients in the United States.

AK602 not only proved effective against viruses that had become resistant to other drugs, but it also caused almost no side effects, the team said.(IHT/Asahi: July 7,2005) <!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->



HOORAY FOR RISK-FREE SEX! =D =D =D
«1

Comments

  • Quantum_MooseQuantum_Moose Join Date: 2005-03-05 Member: 43643Members
    <!--QuoteBegin-Omegaman!+Jul 8 2005, 08:35 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Omegaman! @ Jul 8 2005, 08:35 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> HOORAY FOR RISK-FREE SEX! =D =D =D <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    Ha, wasn't expecting that...
  • NeonSpyderNeonSpyder &quot;Das est NTLDR?&quot; Join Date: 2003-07-03 Member: 17913Members
    Ah, about time.


    I was getting tired of all that risky sex.
  • Dirty_Harry_PotterDirty_Harry_Potter Join Date: 2002-11-21 Member: 9500Members
    though, one might say it's more exciting when it's more dangerous <!--emo&:p--><img src='http://www.unknownworlds.com/forums/html/emoticons/tounge.gif' border='0' style='vertical-align:middle' alt='tounge.gif' /><!--endemo-->
  • DOOManiacDOOManiac Worst. Critic. Ever. Join Date: 2002-04-17 Member: 462Members, NS1 Playtester
    I'm filing this under 'too good to be true' category till it undegoes clinical trials.

    If it is true then it'll be terrific news for the entire world
  • kill4thrillskill4thrills Join Date: 2004-06-24 Member: 29506Members, Constellation
    there are other stds to worry about besides AIDs. i don't think it's safe to go around having unprotected sex with all your friends just yet. AIDs might be sure to kill you, but the other STDs <span style='color:red'><b>burn</b></span> your privates
  • DragonMechDragonMech Join Date: 2003-09-19 Member: 21023Members, Constellation, Reinforced - Shadow
    edited July 2005
    <!--QuoteBegin--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> </td></tr><tr><td id='QUOTE'><!--QuoteEBegin-->If it is true then it'll be terrific news for the entire world<!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->QFT. If this is true, then these people deserve nobel prizes for their work.


    [EDIT] And I'm such a geek - I thought the title said "Hive defeated" >_> <!--emo&:p--><img src='http://www.unknownworlds.com/forums/html/emoticons/tounge.gif' border='0' style='vertical-align:middle' alt='tounge.gif' /><!--endemo-->
  • SwiftspearSwiftspear Custim tital Join Date: 2003-10-29 Member: 22097Members
    <!--QuoteBegin-kill4thrills+Jul 8 2005, 08:49 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (kill4thrills @ Jul 8 2005, 08:49 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> there are other stds to worry about besides AIDs. i don't think it's safe to go around having unprotected sex with all your friends just yet. AIDs might be sure to kill you, but the other STDs <span style='color:red'><b>burn</b></span> your privates <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    tpyo, cue pictures!
  • [WHO]Them[WHO]Them You can call me Dave Join Date: 2002-12-11 Member: 10593Members, Constellation
    edited July 2005
    <!--emo&:0--><img src='http://www.unknownworlds.com/forums/html/emoticons/wow.gif' border='0' style='vertical-align:middle' alt='wow.gif' /><!--endemo-->

    Let's just hope God doesn't respond with fast-acting airborn superAIDS.
  • 2_of_Eight2_of_Eight Join Date: 2003-08-20 Member: 20016Members
    <!--QuoteBegin-DOOManiac+Jul 8 2005, 09:45 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (DOOManiac @ Jul 8 2005, 09:45 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> I'm filing this under 'too good to be true' category till it undegoes clinical trials. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    What I'm thinking - but praying that I'm totally wrong.
  • KGB_GaralKGB_Garal Join Date: 2005-06-09 Member: 53476Members
    Awesome <!--emo&:)--><img src='http://www.unknownworlds.com/forums/html/emoticons/smile-fix.gif' border='0' style='vertical-align:middle' alt='smile-fix.gif' /><!--endemo--> And of course it was made by Asian scientists..
  • CondizzleCondizzle Join Date: 2004-10-05 Member: 32107Members
    Yay! Rampant risk-free pre-marital SEX!
  • baconflapsbaconflaps Join Date: 2004-02-09 Member: 26314Members
    Yeah there aren't a ton of other STDs to contract nope.
  • KGB_GaralKGB_Garal Join Date: 2005-06-09 Member: 53476Members
    <!--QuoteBegin-baconflaps+Jul 8 2005, 06:52 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (baconflaps @ Jul 8 2005, 06:52 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> Yeah there aren't a ton of other STDs to contract nope. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    Don't tell them that.. let them get sick then maybe all the idiots will die off ;p

    AFTER THIS DRUG IS OUT IN CIRCULATION THERE IS NO RISK OF CONTRACTING ANY STD'S THEREFORE IF YOU THINK THAT YOU MIGHT HAVE A STD YOU ACTUALLY DON'T.. SO DO NOT SEEK MEDICAL ATTENTION. Thx.
  • GundamCLGundamCL Join Date: 2003-08-03 Member: 18786Members
    This better not be a prank...
    One would make soo much money distrubuting this wonder drug...
  • Cold_NiTeCold_NiTe Join Date: 2003-09-15 Member: 20875Members
  • CondizzleCondizzle Join Date: 2004-10-05 Member: 32107Members
    <!--QuoteBegin-baconflaps+Jul 8 2005, 09:52 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (baconflaps @ Jul 8 2005, 09:52 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> Yeah there aren't a ton of other STDs to contract nope. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    /me bleeds on Bacon's food.
  • baconflapsbaconflaps Join Date: 2004-02-09 Member: 26314Members
    <!--QuoteBegin-Condizzle+Jul 8 2005, 09:25 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Condizzle @ Jul 8 2005, 09:25 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> <!--QuoteBegin-baconflaps+Jul 8 2005, 09:52 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (baconflaps @ Jul 8 2005, 09:52 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> Yeah there aren't a ton of other STDs to contract nope. <!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->
    /me bleeds on Bacon's food. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    Seriously con you are flipping stupid.
  • Cold_NiTeCold_NiTe Join Date: 2003-09-15 Member: 20875Members
    <!--emo&???--><img src='http://www.unknownworlds.com/forums/html/emoticons/confused-fix.gif' border='0' style='vertical-align:middle' alt='confused-fix.gif' /><!--endemo-->
  • AegeriAegeri Join Date: 2003-02-13 Member: 13486Members
    Firstly, we've seen such 'wonder' treatments before (fused headed antibodies to HIV for example) that have in the long run rather fallen flat. The first problem with the drug is that it doesn't do anything that is particularly new (binding CCR5 has been an idea for a while). Secondly, it would have to be given prophylactically becaue HIV doesn't spend all its time binding CCR5, it changes eventually to attack CXCR4. The problem inherent with simply blocking CCR5 is that macrophages and dendritic cells act as a 'trojan horse', picking up HIV particles and moving them intracellularly as they would anything else they think is interesting. Unfortunately in the case of HIV this is <i>exactly</i> what the virus wants and it gets a free ride to the cells it is really interested in, T-cells, which as I alluded to, express CXCR4 and not CCR5.

    I also question their clinical trial. How long was this trial? Did they monitor T-lymphocyte counts and did they extract and analyse peripheral blood macrophages/langerhans cells to see if they had picked up HIV particles (rendering this treatment rather irrelevant, because HIV can transfer directly cell->cell). Did they investigate if this can actually effectively gain entry into lymph nodes (where T-cells hang out).

    For that matter, I also wonder if they have investigated this in an animal model for its toxicological and pharmacological effects? Looking through the literature currently, I've not been able to find anything about trials they have conducted or the methodology they used to investigate if it is even working.

    Going to the media and not bothering to go through normal publication routes makes me think something suspicious is up.
  • NeonSpyderNeonSpyder &quot;Das est NTLDR?&quot; Join Date: 2003-07-03 Member: 17913Members
    <!--QuoteBegin-Aegeri+Jul 8 2005, 10:54 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Aegeri @ Jul 8 2005, 10:54 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> Firstly, we've seen such 'wonder' treatments before (fused headed antibodies to HIV for example) that have in the long run rather fallen flat. The first problem with the drug is that it doesn't do anything that is particularly new (binding CCR5 has been an idea for a while). Secondly, it would have to be given prophylactically becaue HIV doesn't spend all its time binding CCR5, it changes eventually to attack CXCR4. The problem inherent with simply blocking CCR5 is that macrophages and dendritic cells act as a 'trojan horse', picking up HIV particles and moving them intracellularly as they would anything else they think is interesting. Unfortunately in the case of HIV this is <i>exactly</i> what the virus wants and it gets a free ride to the cells it is really interested in, T-cells, which as I alluded to, express CXCR4 and not CCR5.

    I also question their clinical trial. How long was this trial? Did they monitor T-lymphocyte counts and did they extract and analyse peripheral blood macrophages/langerhans cells to see if they had picked up HIV particles (rendering this treatment rather irrelevant, because HIV can transfer directly cell->cell). Did they investigate if this can actually effectively gain entry into lymph nodes (where T-cells hang out).

    For that matter, I also wonder if they have investigated this in an animal model for its toxicological and pharmacological effects? Looking through the literature currently, I've not been able to find anything about trials they have conducted or the methodology they used to investigate if it is even working.

    Going to the media and not bothering to go through normal publication routes makes me think something suspicious is up. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    You're too smart for our forums.
  • PetcoPetco Join Date: 2003-07-27 Member: 18478Members, Constellation
    edited July 2005
    <!--QuoteBegin-DOOManiac+Jul 8 2005, 06:45 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (DOOManiac @ Jul 8 2005, 06:45 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> I'm filing this under 'too good to be true' category till it undegoes clinical trials. <!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->
    Yeah me too, good thing <!--emo&::gorge::--><img src='http://www.unknownworlds.com/forums/html/emoticons/pudgy.gif' border='0' style='vertical-align:middle' alt='pudgy.gif' /><!--endemo--> s are immune(or don't cause it) to HIV and AIDS...
  • AegeriAegeri Join Date: 2003-02-13 Member: 13486Members
    <!--QuoteBegin-NeonSpyder+Jul 8 2005, 10:56 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (NeonSpyder @ Jul 8 2005, 10:56 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> <!--QuoteBegin-Aegeri+Jul 8 2005, 10:54 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Aegeri @ Jul 8 2005, 10:54 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> Firstly, we've seen such 'wonder' treatments before (fused headed antibodies to HIV for example) that have in the long run rather fallen flat. The first problem with the drug is that it doesn't do anything that is particularly new (binding CCR5 has been an idea for a while). Secondly, it would have to be given prophylactically becaue HIV doesn't spend all its time binding CCR5, it changes eventually to attack CXCR4. The problem inherent with simply blocking CCR5 is that macrophages and dendritic cells act as a 'trojan horse', picking up HIV particles and moving them intracellularly as they would anything else they think is interesting. Unfortunately in the case of HIV this is <i>exactly</i> what the virus wants and it gets a free ride to the cells it is really interested in, T-cells, which as I alluded to, express CXCR4 and not CCR5.

    I also question their clinical trial. How long was this trial? Did they monitor T-lymphocyte counts and did they extract and analyse peripheral blood macrophages/langerhans cells to see if they had picked up HIV particles (rendering this treatment rather irrelevant, because HIV can transfer directly cell->cell). Did they investigate if this can actually effectively gain entry into lymph nodes (where T-cells hang out).

    For that matter, I also wonder if they have investigated this in an animal model for its toxicological and pharmacological effects? Looking through the literature currently, I've not been able to find anything about trials they have conducted or the methodology they used to investigate if it is even working.

    Going to the media and not bothering to go through normal publication routes makes me think something suspicious is up. <!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->
    You're too smart for our forums. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    D:
  • GwahirGwahir Join Date: 2002-04-24 Member: 513Members, Constellation
    a friend of mine was involved with the creation of a virus that caused cells to generate mirror image RNA of HIV that would then bind to the other RNA. I'm told that these mirror image RNA strands are recognised by the body and destroyed. Cellular trials looked good.
  • Cold_NiTeCold_NiTe Join Date: 2003-09-15 Member: 20875Members
    <!--QuoteBegin-Aegeri+Jul 8 2005, 10:59 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Aegeri @ Jul 8 2005, 10:59 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> <!--QuoteBegin-NeonSpyder+Jul 8 2005, 10:56 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (NeonSpyder @ Jul 8 2005, 10:56 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> <!--QuoteBegin-Aegeri+Jul 8 2005, 10:54 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Aegeri @ Jul 8 2005, 10:54 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> Firstly, we've seen such 'wonder' treatments before (fused headed antibodies to HIV for example) that have in the long run rather fallen flat. The first problem with the drug is that it doesn't do anything that is particularly new (binding CCR5 has been an idea for a while). Secondly, it would have to be given prophylactically becaue HIV doesn't spend all its time binding CCR5, it changes eventually to attack CXCR4. The problem inherent with simply blocking CCR5 is that macrophages and dendritic cells act as a 'trojan horse', picking up HIV particles and moving them intracellularly as they would anything else they think is interesting. Unfortunately in the case of HIV this is <i>exactly</i> what the virus wants and it gets a free ride to the cells it is really interested in, T-cells, which as I alluded to, express CXCR4 and not CCR5.

    I also question their clinical trial. How long was this trial? Did they monitor T-lymphocyte counts and did they extract and analyse peripheral blood macrophages/langerhans cells to see if they had picked up HIV particles (rendering this treatment rather irrelevant, because HIV can transfer directly cell->cell). Did they investigate if this can actually effectively gain entry into lymph nodes (where T-cells hang out).

    For that matter, I also wonder if they have investigated this in an animal model for its toxicological and pharmacological effects? Looking through the literature currently, I've not been able to find anything about trials they have conducted or the methodology they used to investigate if it is even working.

    Going to the media and not bothering to go through normal publication routes makes me think something suspicious is up. <!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->
    You're too smart for our forums. <!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->
    D: <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    Yeah I agree. Too smart for this thread.
  • AegeriAegeri Join Date: 2003-02-13 Member: 13486Members
    <!--QuoteBegin-Gwahir+Jul 8 2005, 11:13 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Gwahir @ Jul 8 2005, 11:13 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> a friend of mine was involved with the creation of a virus that caused cells to generate mirror image RNA of HIV that would then bind to the other RNA. I'm told that these mirror image RNA strands are recognised by the body and destroyed. Cellular trials looked good. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    Yes, these have some promise because cells are naturally able to defend themselves against double stranded RNA (they cut it up with enzymes).

    The main point I would suggest with these sorts of press releases is to remember that HIV has been cured several times now by 'miracle' new treatments. There is at least 4-5 miracle HIV treatments that promise to 'end' the disease every year or so. None of these ever manage to go anywhere in particular and never seem to appear again. Scientists seem to have an awfully bad track record for miracle HIV cures :/
  • NuketheplaceNuketheplace Join Date: 2002-09-02 Member: 1266Members
    Interesting fact, Asahi is a beer company. They make almost all the cheep beer in Japan and most of the sodas over there as well.

    I agree with whats been said on this thread. It sounds to good to be true, but if it is, great.
  • RatonetwothreetwooneRatonetwothreetwoone Join Date: 2004-03-23 Member: 27504Members
    edited July 2005
    APRIL FOOLS OOL!!!1 AM I RITE?!?!11
  • AegeriAegeri Join Date: 2003-02-13 Member: 13486Members
    Haha, case in point:

    <a href='http://www.unknownworlds.com/forums/index.php?showtopic=64071&hl=' target='_blank'>http://www.unknownworlds.com/forums/index....topic=64071&hl=</a>

    I knew I'd seen a topic like this earlier.
  • RustySpoonRustySpoon Join Date: 2003-07-10 Member: 18069Members
    <!--QuoteBegin-T h e m+Jul 8 2005, 09:29 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (T h e m @ Jul 8 2005, 09:29 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> <!--emo&:0--><img src='http://www.unknownworlds.com/forums/html/emoticons/wow.gif' border='0' style='vertical-align:middle' alt='wow.gif' /><!--endemo-->

    Let's just hope God doesn't respond with fast-acting airborn superAIDS. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    "Argh! How didn't they die this time? Must be time for a new plague."
  • moultanomoultano Creator of ns_shiva. Join Date: 2002-12-14 Member: 10806Members, NS1 Playtester, Contributor, Constellation, NS2 Playtester, Squad Five Blue, Reinforced - Shadow, WC 2013 - Gold, NS2 Community Developer, Pistachionauts
    <!--QuoteBegin-Aegeri+Jul 8 2005, 10:54 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Aegeri @ Jul 8 2005, 10:54 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> Firstly, we've seen such 'wonder' treatments before (fused headed antibodies to HIV for example) that have in the long run rather fallen flat. The first problem with the drug is that it doesn't do anything that is particularly new (binding CCR5 has been an idea for a while). Secondly, it would have to be given prophylactically becaue HIV doesn't spend all its time binding CCR5, it changes eventually to attack CXCR4. The problem inherent with simply blocking CCR5 is that macrophages and dendritic cells act as a 'trojan horse', picking up HIV particles and moving them intracellularly as they would anything else they think is interesting. Unfortunately in the case of HIV this is <i>exactly</i> what the virus wants and it gets a free ride to the cells it is really interested in, T-cells, which as I alluded to, express CXCR4 and not CCR5.

    I also question their clinical trial. How long was this trial? Did they monitor T-lymphocyte counts and did they extract and analyse peripheral blood macrophages/langerhans cells to see if they had picked up HIV particles (rendering this treatment rather irrelevant, because HIV can transfer directly cell->cell). Did they investigate if this can actually effectively gain entry into lymph nodes (where T-cells hang out).

    For that matter, I also wonder if they have investigated this in an animal model for its toxicological and pharmacological effects? Looking through the literature currently, I've not been able to find anything about trials they have conducted or the methodology they used to investigate if it is even working.

    Going to the media and not bothering to go through normal publication routes makes me think something suspicious is up. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    <span style='color:red'><b><3</b></span>
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