You may have heard of "Trauma Center: Second Opinion", well there is a sequel to the game and it's a great game. Notable changes from the first game.
1. A huge variety of surgeries/operations. Each operation is fairly different than the other, now this is a huge improvement over the first game because the first game had a lot of the same operations over and over.
2. Two player co-op mode, two players can play at the same time for some surgery fun.
3. Widescreen support and full voice acting. Also, online leaderboards.
For those of you who never heard of the games or seen it: It's a surgery simulation game for the Wii, though the game isn't supposed to be "realistic" surgery. Gameplay video 1Gameplay video 2. (BTW, those things in video 2 are "parasites" that you must deal with during the game)